ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Essential Hypertension: Essentially Renal Hypertension? (renal Mechanisms That Have A Role In The Pathophysiology Of Essential Hypertension)
Dr. Çiğdem GÖKÇE,a Dr. Serap DEMİRb
aİç Hastalıkları ve Nefroloji Bölümü, International Hospital, İSTANBULbİç Hastalıkları AD, Nefroloji BD, Afyon Kocatepe Üniversitesi Tıp Fakültesi, AFYON
For a long time after the first description of essential hypertension, it was considered to be associated with secondary but not primary renal dysfunction. However, research concerning animals with genetic hypertension with characteristics similar to human essential hypertension have begun to clarify the role of primary renal functional abnormalities in the pathogenesis of essential hypertension. Recent research indicates that the progress of civilisation has resulted in an increased frequency of hypertension in humans, due to their ingesting higher amounts of salt than they are evolutionally adapted to. The most likely underlying renal problems in humans genetically predisposed to hypertension are considered to be, decreased renal elimination of sodium and water and/or increased resistance to blood flow. Functional renal abnormalities leading to hypertension can be transplanted along with the kidney. Emergence of hypertension without the contribution of such functional renal abnormalities seems unlikely. Findings similar to those of genetically hypertensive animal models have been observed in humans with essential hypertension, leading to growing appreciation of the contributory roles of the kidneys in the pathogenesis of essential hypertension. In conclusion, it can be said that, “Essential hypertension is essentially renal hypertension”. The purpose of this article is to review the renal mechanisms associated with the pathogenesis of essential hypertension as well as its treatment, to facilitate better comprehension of treatment options and to highlight aspects still awaiting research.Keywords: Essential hypertension, kidney, sodiumTurkiye Klinikleri J Int Med Sci 2005, 1(38):18-24
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