ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Renal Parenchymal Hypertension In Children
Dr. Zelal BİRCANa
aÇocuk Nefrolojisi BD, Kocaeli Üniversitesi Tıp Fakültesi, KOCAELİ
The cause of secondary hypertension (HT) in 60-80% of children is renal parenchymal pathology. The most common causes of HT due to renal parenchymal pathology are glomerulonephritis and reflux nephropathy. Detailed history, physical examination and basic laboratory screening may be helpful in differential diagnosis of renal parenchymal diseases.
HT occuring secondary to renal causes is generally a result of salt and water retention and high plasma renin activity. Acute and chronic glomerular diseases, renal hypoplasia, obstructive uropathy and reflux nephropathy are pathological causes that result in HT associated with these mechanisms.
In congenital or acquired renal parenchymal diseases, renin-angiotensin system activation is the basic determinator of HT and progression of renal parenchymal damage. Therefore, angiotensin converting enzyme inhibitors and angiotensin receptor blockers are the drugs of choice in the regulation of blood pressure and protection of renal functions. Ramipril and losartan should be preferred in childhood renal parenchymal hypertension because of their previously shown efficacy and safety.Keywords: Children, renal parenchym, hypertension, treatmentTurkiye Klinikleri J Int Med Sci 2005, 1(38):44-49
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