ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Biochemical Investigations In The Differential Diagnosis Of Hypertension
Dr. Mustafa SERTESERa
aBiyokimya AD, Afyon Kocatepe Üniversitesi Tıp Fakültesi, AFYON
The etiology of hypertension is not clear in 90-95% of the patients. On the other hand, renal artery stenosis, renal parenchymal diseases, coarctation of the aorta, pheochromocytoma, hyperaldosteronism, oral contraceptives, Cushing’s Syndrome, adrenogenital syndrome, thyroid diseases, hyperparathyroidism and acromegaly are among the secondary causes of hypertension. Serum glucose, BUN, creatinine and uric acid levels, lipid profile testing, calcium, sodium, potassium and chloride levels, whole blood count, urinalysis, urinary sediment analysis and microalbuminuria are the major basic tests to be performed for all hypertensive patients. Serum BUN and creatinine levels and urinalysis are important in the differential diagnosis of renal parenchymal diseases. Measurement of renal vein renin is important in the diagnosis of renal artey stenosis. The dexamethasone supression test is used in the diagnosis of Cushing’s Syndrome while catecholamines, metaneprine and vanilmandelic acid measurements in 24-hour urine samples are used in the diagnosis of pheochromocytoma. In primary aldosteronism, plasma renin activity and plasma aldosteron concentration are the basic tests to be performed. In this paper, the use of biochemical tests in the differential diagnosis of hypertension is discussed. Moreover, the time and the type of sampling and pre-analytical factors will be evaluated.Keywords: Hypertension, biochemical tests, renin,anjiotensin, aldosteroneTurkiye Klinikleri J Int Med Sci 2005, 1(38):70-76
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