ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Membranoproliferative Glomerulonephritis
Dr. İbrahim KARAYAYLALIa
aNefroloji BD, Çukurova Üniversitesi Tıp Fakültesi, ADANA
Membranoproliferative Glomerulonephritis (MPGN), or mesangiocapillary glomerulonephritis, is characterized by proliferative lesions, hypercellular due to influx of leukocytes and intrinsic glomerular cell proliferation, and widening of the capillary loops. MPGN is one of the major causes of nephrotic syndrome and accounts for aproximately 5% to 20% of primary glomerulonephritis. MPGN may be primary (idiopathic) or secondary to chronic immune-complex disease, chronic infection, cryoglobulinemia, HCV infection, partial lipodystrophy, sickle cell disease. On the basis of analysis of renal biopsy, three types are described MPGN type I and III are variants of immuncomplex -mediated disease, MPGN Type II (Dense Deposit Disease) is linked to overactivation of alternative pathway of complement. MPGN is associated with low complement levels, and often cryoglobulinemia. Treatment of MPGN is based on describing the etiology, and reducing proteinuria and lowering high blood pressure, There is no effective treatment for MPGN. Corticosteroids and immunosupppresants, anticoagulants, anti thrombolytics, plasmapheresis, and plasma exchange have been used for treatment in MPGN.Keywords: Membranoproliferative, glomerulonephritis, C3 nephrotic factor, hypocomplementemiaTurkiye Klinikleri J Int Med Sci 2006, 2(21):25-30
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