ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Thrombotic Thrombocytopenic Purpura And Hemolytic Uremic Syndrome
Dr. Ali ÇELİKa
aNefroloji BD, Dokuz Eylül Üniversitesi Tıp Fakültesi, İZMİR
Thrombotic microangiopathy (TMA) is microvascular occlusive disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organ injury due to platelet thrombosis in the microcirculation. Depending on whether brain or renal lesions prevail, two pathologically similar but clinically distint entities are described: thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). TTP usually affect adults, and is characterized by severe neurologic involvement in most cases, and variable renal involvement. HUS occurs in young children, and is characterized by acute renal failure, and absent or minimal neurologic abnormalities. In this review, the clinic features, diagnosis, pathophysiology, and treatment of the thrombotic microangiopathy were discussed.Keywords: Purpura, thrombotic thrombocytopenic; hemolytic-uremic syndromeTurkiye Klinikleri J Int Med Sci 2007, 3(4):30-35
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