ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Henoch-schÖnlein Purpura, Essential Mixed Cryoglobulinemia, Antiphospholipid Syndrome And Kidney
Dr. M. Tuğrul SEZERa
aNefroloji BD, Süleyman Demirel Üniversitesi Tıp Fakültesi, ISPARTA
Henoch-Schönlein purpura (HSP) is a systemic vasculitis with a prominent cutaneous component. It is characterized by the tissue deposition of IgA-containing immune complexes. The pathogenesis of this disorder may be similar to that of IgA nephropathy. HSP occurs more often in children than in adults, but renal involvement is more likely to occur, and to be severe, in older children and in adults, prompting more aggressive therapy. Essential mixed cryoglobulinemia, also called type II cryoglobulinemia, is most often induced by hepatitis C virus infection. The main indication for therapy is progressive systemic disease affecting the small blood vessels, kidneys, liver, or peripheral nerves. The prognosis of the renal disease is variable. The antiphospholipid syndrome (APS) is characterized by antibodies directed against either phospholipids or plasma proteins bound to anionic phospholipids. Patients with the APS may display a constellation of clinical features including venous and arterial thrombosis, recurrent fetal losses, and thrombocytopenia. This disorder is referred to as the primary APS when it occurs alone; however, it can also be found in association with systemic lupus erythematosus, other rheumatic diseases, and with certain infections and drugs. Renal complications directly resulting from thrombotic events associated with these antibodies include glomerular disease, large vessel renal involvement, and coagulation problems relating to dialysis and renal transplants. Standard therapy of thrombosis in patients with the APS commonly consists of heparin, followed by warfarin.Keywords: Purpura, schoenlein-henoch; cryoglobulinemia; antiphospholipid syndrome; vasculitis; kidneyTurkiye Klinikleri J Int Med Sci 2007, 3(4):52-64
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