ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Renal Tubular Acidosis
Dr. Ramazan ÇETİNKAYAa, Dr. Mustafa KELEŞ,a Dr. Abdullah UYANIKa
aNefroloji BD, Atatürk Üniversitesi Tıp Fakültesi, ERZURUM
The kidneys maintain acid-base balance by bicarbonate reclamation and acid excretion. Renal Tubular Acidosis (RTA) is a group of syndromes of renal tubular dysfunction characterized by either an impaired bicarbonate absorption or hydrogen ion secretion that is out of proportion to the glomerular filtration rate. The RTA syndromes are manifested by a normal anion gap and hyperchloremic metabolic acidosis (HCMA) with either hypokalemia, normokalemia or hyperkalemia. The RTA syndromes are classically divided into 3 forms. Proximal RTA is a disorder leading to HCMA secondary to impaired proximal reabsorption of filtered bicarbonate and distal RTA is a disorder leading to HCMA secondary to diminished distal H+ secretion. Type 4 RTA is characterized by HCMA with normal anion gap and association with hyperkalemia. In patients with RTA, isolated defects in urine asidification function are rarely found. Most patients with RTA will have multiple defects in tubular function. In this article, we will discuss pathophysiology, classification, diagnosis and therapy of the RTA syndromes.Keywords: Acidosis; acidosis, renal tubularTurkiye Klinikleri J Int Med Sci 2007, 3(21):27-36
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